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Under the requirements of MOE Notification 2021-23, the scope of existing substances has been revised. Details are as follows:

Hydrates or anhydrates of existing substances are all considered as existing substances;
Reaction products composed of two or more components, and each component is an existing substance (these components are difficult to separate by technical means, and the reaction product itself is distributed or used in the market). Under this circumstance, the reaction products are also considered as existing substances; and
If an existing substance has two or more configurations, then each specific configuration is regarded as an existing substance;

Substances that have listed in Annex 3 are as follows:

KE No.	Chemical Name (CAS No.)
97-1-4	Guazatine, salts
97-1-9	Lead compounds
97-1-11	Nicotine, salts
97-1-39	DNOC, salts
97-1-57	Lasalocid, salts
97-1-87	Monensin, salts
97-1-90	Inorganic cyanide compounds
97-1-91	Inorganic zinc, salts
97-1-92	Inorganic silver, salts
97-1-93	Inorganic tin, salts
97-1-102	Benzidine (CAS No. 92-87-5)
97-1-102	Benzidine, salts
97-1-117	Blasticidin-S, salts
97-1-119	Arsenic compounds
97-1-131	Salinomycin, salts

97-1-134	Selenium compounds
97-1-138	Triaryl tin hydroxide((Contains anhydride of Triaryl tin hydroxide)
97-1-138	Triaryl tin hydroxide, salts
97-1-139	Trialkyl tin hydroxide
97-1-139	Trialkyl tin hydroxide, salts
97-1-139	Tributyltin compound
97-1-140	Mercury compounds
97-1-144	Strychnine, salts
97-1-155	Anabasin, salts
97-1-156	Aniline, salts
97-1-167	Nitrous acid, salts
97-1-176	Inorganic antimony compounds
97-1-183	Alkyl aniline
97-1-183	Alkyl aniline, salts
97-1-198	Chloric acid, salts
97-1-200	N-Alkyldimethylbenzylammonium chloride
97-1-219	Warfarin, salts
97-1-250	Cadmium compounds
97-1-258	Cartap, salts
97-1-271	Chromic acid, salts
97-1-272	Crimidine, salts
97-1-286	Chlordimeform, salts
97-1-296	Tetraalkyl lead
97-1-299	Toluenediamine, salts
97-1-300	Toluidine, salts
97-1-323	Paraquat, salts
97-1-334	Phenylenediamine, salts
97-1-339	Pentachlorophenol, salts
97-1-376	Fluorosilicic acid, salts
97-1-377	Fluoroboric acid, salts
97-1-379	Fluoroacetic acid, salts
97-1-395	Picric acid, salts
97-1-397	Piproctanyl, salts
97-1-411	Hydroxylamine, salts
97-1-412	2-Naphthylamine hydrochloride (612-52-2)
97-1-417	p-Dimethylaminobenzenediazo sulfonate, salts

97-1-425	2,4-Dichloro-6-nitrophenol, salts
97-1-451	N-Alkyl toluidine
97-1-451	N-Alkyl toluidine, salts
97-1-468	2-Hydrazinoethanol, salts
99-1-506	Dichromic acid, salts
2000-1-509	Cetrimonium, salts
2005-1-547	3,3'-Dichlorobenzidine, salts
06-4-13	Benzidine sulfate (1:1) (CAS No. 531-86-2)
06-4-13	Benzidine sulfate (CAS No. 21136-70-9)
06-4-14	Strychnine arsenate (CAS No. 10476-82-1)
06-4-14	Strychnine dimethylarsinate (CAS No. 10476-87-6)
06-4-14	Strychnine glycerophosphate (CAS No. 1323-31-5)
06-4-14	Strychnine hydrochloride (CAS No. 1421-86-9)
06-4-14	Strychnine phosphate (CAS No. 509-42-2)
06-4-14	Strychnine sulphate (CAS No. 60-41-3)
06-4-14	Strychnine sulfate pentahydrate (CAS No. 60491-10-3)
06-4-27	Anthophyllite asbestos (77536-67-5)
06-4-27	Actinolite asbestos (77536-66-4)
06-4-27	Tremolite asbestos (77536-68-6)
06-4-32	Chlordimeform, salts
06-4-32	Chlordimeform hydrochloride (CAS No. 19750-95-9)
06-4-47	Phenylmercuric triethanol ammonium borate
06-4-49	Pentachlorophenol, salts
06-4-49	Pentachlorophenol potassium salt; potassium pentachlorohenolate (CAS No. 7778-73-6)
06-4-49	Tributyltin pentachlorophenolate (CAS No. 3644-38-0)
06-5-1	Malachite green, salts
06-5-1	Malachite green (CAS No. 10309-95-2)
06-5-6	Nonylphenols
06-5-6	Nonylphenol ethoxylates
06-5-6	Nonylphenol ethoxylates (CAS No. 27177-05-5)
06-5-10	Chromium(6+) compounds
06-5-10	Chromium, ion (Cr6+) (CAS No. 18540-29-9)

The Amendments has been implemented from 12 Aug. 2021.

CIRS warmly reminds that related enterprises should make reference to the latest amendments to existing substances when they determine whether their substances are existing substances or new substances.

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The Scope of Existing Substances under K-REACH has been Revised